Codexis announces cellulase enzyme scale-up

July 14, 2011, Redwood City, CA – Codexis has
announced the first scale-up manufacturing of its proprietary cellulase enzymes
at commercial scale. These enzymes are used to convert non-food biomass to
fermentable sugars and ultimately to products such as biofuels and bio-based
performance ingredients in household goods such as laundry detergents and
shampoos.

Scale-up manufacturing of a prototype
cellulase enzyme product is underway at Fermic S.A. de C.V, a contract
fermentation and synthesis company headquartered in Mexico City, Mexico. Enzyme
production has been successfully completed at 20,000-litre scale and represents
the first manufacture of an enzyme product using the Codexis CodeXporter enzyme
expression system. The cellulase enzymes are based on the Codexis CodeEvolver
directed evolution technology and will be used to support biofuels
collaborations and the company's market expansion into sustainable bio-based
chemicals.